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<h2>Ito - Figure 3 - Impact of statin Rx</h2>

  <p>
This Figure shows the impact of statin treatment on a Japanese patient population.

In this study<span class='ref_num'>[24]</span> the investigators looked at the age of onset of CHD in patients

receiving statins versus those not receiving statins during 2 time periods
<ul>
  <li>prior to September 1989 when pravastatin became available in Japan</li>
  <li>after September 1989</li>
</ul>

The Figure shows this distribution when the CHD was first identified in these individuals,

stratified by men and women. The blue bars are the distribution of the age of onset of

CHD in patients not receiving statins and the yellow bars are the same distribution for

patients receiving statins. It can be seen that for men the age of CHD onset was about

40 years whereas it was about 50 years in women, but for patients on statin therapy,

the distributions are now skewed to the right by about 10 years. In other words, statin

therapy delayed the onset of CAD by about 10 years, and this was an independent

predictor even after multivariate analysis for other confounding factors.
</p>
<span class='figuretext_source_identifier'>
  <span class="author">Ito MK.</span>
  <span class="publication">J Clin Lipidol.</span>
  <span class="identifier">2011; 5(6).</span>
</span>

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  <h2>References</h2>
  <p>
    <span class='ref_num'>[24]</span>Harada-Shiba M, Sugisawa T, Makino H, et al. Impact of Statin Treatment on the
Clinical Fate of Heterozygous Familial Hypercholesterolemia. J Atheroscler THromb
2010;17:667-674.
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