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Complete References

Goldberg

[1](Goldberg - figure 3) US MedPed program. www.medped.org.medped.org

[2](Goldberg - figure 3) Simon Broome Register Group. Risk of fatal coronary heart disease in familial hypercholesterolaemia. BMJ 1991;303:893-896.

[3](Goldberg - figure 3) Versmissen J, Oosterveer DM, Yazdanpanah M, et al. Efficacy of statins in familial hypercholesterolaemia: A long-term cohort study. BMJ 2008; 337: a2423.

[4](Goldberg - figure 3) Newson, A. J., Humphries, S. E. Cascade testing in familial hypercholesterolaemia: how should family members be contacted? Europ. J. Hum. Genet. 13: 401-408, 2005.

Robinson

[5](Robinson - figure 2) Versmissen J, Oosterveer DM, Yazdanpanah M, et al. Efficacy of statins in familial hypercholesterolaemia: A long-term cohort study. BMJ 2008; 337: a2423.

[6](Robinson - figure 4) The Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994; 344: 1383-1389.

[7](Robinson - figure 4) Shepherd J, Cobbe SM, Ford I, et al, for the West of Scotland Coronary Prevention Study Group. Prevention of coronary heart disease with pravastatin in men with Hypercholesterolemia. NEJM 1995; 333: 1301 – 1307.

[8](Robinson - figure 4) Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebo controlled trial. Lancet 2002; 360: 7–22

[9](Robinson - figure 4) LaRosa JC, Grundy SM, Waters DD, et al. Intensive Lipid Lowering with Atorvastatin in Patients with Stable Coronary Disease. N ENgl J Med 2005; 352:

[10](Robinson - figure 4) Cannon CP, Braunwald E, McCabe CH, et al. Intensive versus Moderate Lipid Lowering with Statins after Acute Coronary Syndromes. N Engl J Med 2004; 350:1495-504.

[11](Robinson - figure 5) Kastelein JJP, Akdim F, Stroes ESG, et al. Simvastatin with or without Ezetimibe in Familial Hypercholesterolemia. N Engl J Med 2008; 358:1431-1443.

[12](Robinson - figure 5) Sivapalaratnam S, van Loendersloot LL, Hutten BA, et al. Long-term LDL-c lowering in heterozygous familial hypercholesterolemia normalizes carotid intima-media thickness. Atherosclerosis 2010;212:571-574.

[13](Robinson - figure 10) The Coronary Drug Project Research Group. Clofibrate and niacin in coronary heart disease. JAMA 1975;231:360-81.

[14](Robinson - figure 10) Buchwald H, Varco R, et al. Effect of partial ileal bypass surgery on mortality and morbidity from coronary heart disease in patients with hypercholesterolemia. Report of the Program on the Surgical Control of the Hyperlipidemias (POSCH). N Engl J Med 1990; 323: 946-955.

[15](Robinson - figure 11) Rosseb AB, Pedersen TR, Boman K, et al. Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. N Engl J Med. 2008;359.

[16](Robinson - figure 11) Baigent C, Landray MJ, Reith C, et al. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomized placebo-controlled trial. The Lancet 2011; Published Online June 9, 2011 DOI:10.1016/S0140-6736(11)60739-3

[17](Robinson - figure 11) The ACCORD investigators. Effects of combination lipid therapy in type 2 diabetes mellitus. N Engl J Med 2010; DOI: 10.1056/NEJMoa1001282. Available at: http://www.nejm.org/

Gidding

[18](Gidding - figure 8) Cornhill JF, Herderick EE, Vince DG. The clinical morphology of human atherosclerotic lesions. Lessons form the PDAY studay. Pathobiological Determinants of Atherosclerosis in Youth. Wien Klin Wochenschr 1995;107(18): 540-543.

[19](Gidding - figure 13) Wiegman A, Hutten BA, de Groot E, et al. Efficacy and Safety of Statin Therapy in Children With Familial Hypercholesterolemia. JAMA 2004; 292(3); 331-337.

Toth

[20](Toth - figure 6) Hopkins PN, Stephenson S, Wu LL, et al. Evaluation of coronary risk factors in patients with heterozygous familial hypercholesterolaemia. Am J Cardiol 2001;87:547–53.

[21](Toth - figure 15) US MedPed program. www.medped.org

[22](Toth - figure 15) Versmissen J, Oosterveer DM, Yazdanpanah M, et al. Efficacy of statins in familial hypercholesterolaemia: A long-term cohort study. BMJ 2008; 337: a2423.

[23](Toth - figure 15) Simon Broome Register Group. Risk of fatal coronary heart disease in familial hypercholesterolaemia. BMJ 1991;303:893-896.

Ito

[24](Ito - figure 2) Harada-Shiba M, Sugisawa T, Makino H, et al. Impact of Statin Treatment on the Clinical Fate of Heterozygous Familial Hypercholesterolemia. J Atheroscler THromb 2010;17:667-674.

[25](Ito - figure 5) Stein EA, Ballantyne CM, Windler E, et al. Efficacy and Tolerability of Fluvastatin XL 80 mg Alone, Ezetimibe Alone, and the Combination of Fluvastatin XL 80 mg With Ezetimibe in Patients With a History of Muscle-Related Side Effects With Other Statins. Am J Cardiol 2007;101:490-496.

[26](Ito - figure 6) Backes JM, Moriarty PM, RUisinger JF, Gibson CA. Effects of Once Weekly Rosuvastatin Among Patients With a Prior Statin Intolerance. Am J Cardiol 2007;100:554–555

[27](Ito - figure 13) Buchwald H, Varco RL, Matts JP, et al. Effect of partial ileal bypass surgery on mortality and morbidity from coronary heart disease in patients with hypercholesterolemia. Report of the Program on the Surgical Control of the Hyperlipidemias (POSCH). N Engl J Med. 1990 Oct 4;323(14):946-55.

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