Toth - Figure 16 - Diagnosis (MEDPED, etc.)
Formal clinical diagnosis of FH can be made by applying any one of several validated
sets of criteria, which include the following three:
- In the United States there is widespread use of the Make Early Diagnosis to
Prevent Early Death, or MEDPED, criteria.[21]
- In Holland the Dutch Lipid Clinic Network system has been used.[22]
- In Great Britain, the Simon Broome Register Group has been developed.[23]
It should be noted that LDL cholesterol cut-points usually vary with age. The clinical
diagnosis of FH is most likely when ≥2 first-degree relatives are found to have elevated
LDL cholesterol in the range noted above, when pediatric cases are identified within the
family, or when the patient or a close relative has tendinous xanthomas.
Toth PP.
J Clin Lipidol.
2011; 5(6).
Complete references for all slides
References
[21]US MedPed program. www.medped.org
[22]Versmissen J, Oosterveer DM, Yazdanpanah M, et al. Efficacy of statins in familial
hypercholesterolaemia: A long-term cohort study. BMJ 2008; 337: a2423.
[23]Simon Broome Register Group. Risk of fatal coronary heart disease in familial
hypercholesterolaemia. BMJ 1991;303:893-896.
