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The Figure underscores a statistically significantly greater reduction in intracranial hemorrhage with each of the new agents compared with warfarin.[118] Again, risk versus effect must be carefully considered by physicians and their patients, but probably most individuals would prefer the risk of a bleed to the risk of a stroke, especially if part of that bleeding risk is not going to be in the head.
Reiffel JA. Am J Med 2013; 126: 00-00.
[118] Tendera M, Syzdół M, Parma Z. ARISTOTLE RE-LYs on the ROCKET. What's new in stroke prevention in patients with atrial fibrillation? Cardiol J. 2012;19:4-10.