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Again the corollary to anticoagulant therapy is risk of bleeding, and the Figure shows the curves for major bleeding events with apixaban.[99] Apixaban was clearly superior to warfarin for this result, with a risk reduction of 31% (p<0.001). This stands in contrast to rivaroxaban and dabigatran, where the risk of major bleeding was similar to that with warfarin.
Reiffel JA. Am J Med 2013; 126: 00-00.
[99] Granger CB, Alexander JH, McMurray JV, et al; the ARISTOTLE Committees and Investigators. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011;365:981-992.