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<h3 class='figure_identifier'>James A. Reiffel, MD - Novel Oral Anticoagulants - Figure 47</h3>
<h2>ARISTOTLE: Primary Outcome</h2>


<div class='figure_text' speaker='reiffelB' figure='47'>
      <P><SPAN class='\"GingerNoCheckStart\"'></SPAN>The <B>Figure </B>shows the curves for the percentage of patients with <SPAN class='\"\\"GRcorrect\\"\"' gruiphraseguid='\"\\"57d9f3b5-7737-41ff-8478-bfa88d8beea3\\"\"' grmarkguid='\"\\"50a9c904-9c82-4415-8b80-7e71d2aba757\\"\"' grcontextid='\"\\"an:0\\"\"'>an</SPAN> primary outcome event (stroke or systemic embolism) per time<SPAN mso-bidi-font-weight:bold\\\?='\"\"' mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa;='\"\"' roman&quot;;='\"\"' roman&quot;;mso-bidi-font-family:&quot;times='\"\"' new='\"\"' mso-fareast-font-family:&quot;times='\"\"'>.<span class='ref_num'>[99]</span> </SPAN>The result was a hazard ratio of 0.79 with <SPAN class='\"\\"GRnoSuggestion\"' gruiphraseguid='\"\\"8e15459f-26d2-4deb-8867-0a9d06a1c16a\\"\"' grmarkguid='\"\\"df2b1b54-17f8-4e59-bf02-63fb4dc36aec\\"\"' grcontextid='\"\\"apixaban:0\\"\"' grcorrect\\\?='\"\"'>apixaban</SPAN>, p=0<SPAN class='\"\\"GRcorrect\\"\"' gruiphraseguid='\"\\"8e15459f-26d2-4deb-8867-0a9d06a1c16a\\"\"' grmarkguid='\"\\"f8d9a0ff-c401-49be-8579-c64389072043\\"\"' grcontextid='\"\\".:1\\"\"'>.</SPAN>011. &nbsp;These data are similar to the results with <SPAN class='\"\\"GRnoSuggestion\"' gruiphraseguid='\"\\"f31b612c-aa04-44d0-af41-a415da010464\\"\"' grmarkguid='\"\\"e31511e5-fcb4-4cc0-a89b-73d34091db38\\"\"' grcontextid='\"\\"dabigatran:0\\"\"' grcorrect\\\?='\"\"'>dabigatran</SPAN> in RE-LY,<SPAN mso-bidi-font-weight:bold\\\?='\"\"' mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa;='\"\"' roman&quot;;='\"\"' roman&quot;;mso-bidi-font-family:&quot;times='\"\"' new='\"\"' mso-fareast-font-family:&quot;times='\"\"'><span class='ref_num'>[96]</span> </SPAN><SPAN class='\"\\"GRcorrect\\"\"' gruiphraseguid='\"\\"49058020-c402-4263-a4c6-1fc47bb07114\\"\"' grmarkguid='\"\\"4f31e1b6-bd61-4161-b74b-250223cdbe85\\"\"' grcontextid='\"\\"which:0\\"\"'>which</SPAN> are shown in a following Figure.</P>
<P>&nbsp;<B><SPAN class='\"\\"GRnoSuggestion\"' gruiphraseguid='\"\\"8bb0c13a-8bce-4661-8983-1dcd15fc36c5\\"\"' grmarkguid='\"\\"63f76b1a-278f-437b-b72d-f39317b541dd\\"\"' grcontextid='\"\\"Reiffel:0\\"\"' grcorrect\\\?='\"\"'>Reiffel</SPAN> JA. <I>Am J <SPAN class='\"\\"GRcorrect\\"\"' gruiphraseguid='\"\\"1a0433f6-0fd2-495b-a842-c85a9ead07e0\\"\"' grmarkguid='\"\\"08b0898e-fbb6-48d6-a8f5-a36e1d3b08a3\\"\"' grcontextid='\"\\"Med:0\\"\"'>Med</SPAN></I> 2013; 126: 00-00.</B><BR class='\"\\"aloha-end-br\\"\"'></P><SPAN class='\"GingerNoCheckEnd\"'></SPAN>  </div>


  <div class='figure_references' speaker='reiffelB' figure='47'>
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  <a href="complete_references.php" class="noprint right resource_link buttonify" target_orig="_blank">Complete references for all slides</a>
  <h2>References</h2>
    <p>
    <span class="ref_num">[96]</span> Connolly SJ, Ezekowitz MD, Yusuf S, et al; RE-LY Steering Committee and Investigators. Dabigatran versus warfarin in patients with atrial fibrillation. <i>N Engl J Med.</i> 2009;361:1139-1151.  </p>
    <p>
    <span class="ref_num">[99]</span> Granger CB, Alexander JH, McMurray JV, et al; the ARISTOTLE Committees and Investigators. Apixaban versus warfarin in patients with atrial fibrillation. <i>N Engl J Med.</i> 2011;365:981-992.  </p>
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