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<h3 class='figure_identifier'>James A. Reiffel, MD - Novel Oral Anticoagulants - Figure 35</h3>
<h2>ROCKET AF: Rivaroxaban vs Warfarin</h2>


<div class='figure_text' speaker='reiffelB' figure='35'>
      <P>The <B>Figure</B> shows the ITT analysis of the results<SPAN style="FONT-FAMILY: 'Arial', 'sans-serif'" mso-bidi-font-weight:bold\?="" mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa;="" roman&quot;;="" roman&quot;;mso-bidi-font-family:&quot;times="" new="" mso-fareast-font-family:&quot;times="" 12.0pt? font-size:>.<span class='ref_num'>[97]</span> </SPAN>For <SPAN class='\"GRnoSuggestion' grmarkguid='\"6343f479-97b7-463b-a8ec-03d3e6d6a230\"' grcontextid='\"rivaroxaban:0\"' gruiphraseguid='\"87f9ce17-6f63-4d4f-a309-0f1f8619a5f1\"' grcorrect\?="">rivaroxaban</SPAN> <SPAN class='\"GRnoSuggestion' grmarkguid='\"445b5461-e7a7-4821-953e-63eb18550f86\"' grcontextid='\"vs:1\"' gruiphraseguid='\"87f9ce17-6f63-4d4f-a309-0f1f8619a5f1\"' grcorrect\?="">vs</SPAN> <SPAN class='\"GRnoSuggestion' grmarkguid='\"a733fc94-530a-4565-bf2b-93f8dc01966a\"' grcontextid='\"warfarin:2\"' gruiphraseguid='\"87f9ce17-6f63-4d4f-a309-0f1f8619a5f1\"' grcorrect\?="">warfarin</SPAN>&nbsp;these results were 2.1 <SPAN class='\"GRnoSuggestion' grmarkguid='\"07beff92-8371-4031-b544-3b90a572b5c8\"' grcontextid='\"vs:3\"' gruiphraseguid='\"87f9ce17-6f63-4d4f-a309-0f1f8619a5f1\"' grcorrect\?="">vs</SPAN> 2.4 events per 100 patient-years, respectively. &nbsp;The difference was just short of statistical nonsignificance, meaning that <SPAN class='\"GRnoSuggestion' grmarkguid='\"e65ef3a9-eaf4-44ae-b065-12dad6a49663\"' grcontextid='\"rivaroxaban:0\"' gruiphraseguid='\"9b192bfa-3427-4c7a-86fd-8a544cefe9ed\"' grcorrect\?="">rivaroxaban</SPAN> was <SPAN class='\"GRnoSuggestion' grmarkguid='\"1f9483f5-2e4b-4567-a72a-6a6014044c67\"' grcontextid='\"noninferior:1\"' gruiphraseguid='\"9b192bfa-3427-4c7a-86fd-8a544cefe9ed\"' grcorrect\?="">noninferior</SPAN>, but just short of superior, to <SPAN class='\"GRnoSuggestion' grmarkguid='\"8490d037-f127-45c2-8a85-c88e7c20058d\"' grcontextid='\"warfarin:2\"' gruiphraseguid='\"9b192bfa-3427-4c7a-86fd-8a544cefe9ed\"' grcorrect\?="">warfarin; put another way, </SPAN>the efficacy of <SPAN class='\"GRnoSuggestion' grmarkguid='\"3a429036-8085-4c00-8be0-56e471b8add5\"' grcontextid='\"rivaroxaban:0\"' gruiphraseguid='\"e8ea3b54-201a-4fff-abcd-4c31b8e7a9ac\"' grcorrect\?="">rivaroxaban</SPAN> was at least as <SPAN class='\"GRcorrect\"' grmarkguid='\"00956b08-7bbd-48d6-9593-8004e8a3dd8f\"' grcontextid='\"good:1\"' gruiphraseguid='\"e8ea3b54-201a-4fff-abcd-4c31b8e7a9ac\"'>good</SPAN> as the efficacy of <SPAN class='\"GRnoSuggestion' grmarkguid='\"92b5e3c8-4657-43f9-b447-52c8b8074508\"' grcontextid='\"warfarin:2\"' gruiphraseguid='\"e8ea3b54-201a-4fff-abcd-4c31b8e7a9ac\"' grcorrect\?="">warfarin</SPAN>.&nbsp;</P>
<P>&nbsp;<B><SPAN class='\"GRnoSuggestion' grmarkguid='\"f66d05e4-05da-41b5-9b30-9aa3caa2a057\"' grcontextid='\"Reiffel:0\"' gruiphraseguid='\"5ec2fd1e-aea8-48a2-9ec4-0409aef8b105\"' grcorrect\?="">Reiffel</SPAN> JA. <I>Am J <SPAN class='\"GRcorrect\"' grmarkguid='\"f277ad61-1c71-429f-9ef7-65fbd333ecff\"' grcontextid='\"Med:0\"' gruiphraseguid='\"05c6e2cc-44ec-4631-9e23-3415ed79c57a\"'>Med</SPAN></I> 2013; 126: 00-00.</B><BR class='\"aloha-end-br\"'></P>  </div>


  <div class='figure_references' speaker='reiffelB' figure='35'>
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  <a href="complete_references.php" class="noprint right resource_link buttonify" target_orig="_blank">Complete references for all slides</a>
  <h2>References</h2>
    <p>
    <span class="ref_num">[97]</span> Patel MR, Mahaffey KW, Garg J, et al; the ROCKET AF Steering Committee, for the ROCKET AF Investigators. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. <i>N Engl J Med.</i> 2011;365:883-891.  </p>
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