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<h3 class='figure_identifier'>James A. Reiffel, MD - Novel Oral Anticoagulants - Figure 25</h3>
<h2>RE-LY: Adverse Reactions</h2>


<div class='figure_text' speaker='reiffelB' figure='25'>
      <P>As can be seen in the <B>Figure</B>, the most frequent adverse reactions pertaining to <SPAN class='\"\\"GRnoSuggestion\"' grcontextid='\"\\"dabigatran:0\\"\"' grmarkguid='\"\\"94c5cd42-dcf6-4411-a750-eaa8fe50167f\\"\"' gruiphraseguid='\"\\"bacc8c94-6284-412c-bcc8-92a662ef2f1b\\"\"' grcorrect\\\?='\"\"'>dabigatran</SPAN> in the RE-LY trial were GI events, with about a 5% higher incidence of discontinuation due to GI reactions with <SPAN class='\"\\"GRnoSuggestion\"' grcontextid='\"\\"dabigatran:1\\"\"' grmarkguid='\"\\"8c41c836-8db5-494c-8dfa-372e7505779a\\"\"' gruiphraseguid='\"\\"bacc8c94-6284-412c-bcc8-92a662ef2f1b\\"\"' grcorrect\\\?='\"\"'>dabigatran</SPAN> than with <SPAN class='\"\\"GRnoSuggestion\"' grcontextid='\"\\"warfarin:2\\"\"' grmarkguid='\"\\"7203c609-5ee4-4e6e-848b-6d8b43ebb7da\\"\"' gruiphraseguid='\"\\"bacc8c94-6284-412c-bcc8-92a662ef2f1b\\"\"' grcorrect\\\?='\"\"'>warfarin,</SPAN> and with about 20% of subjects experiencing GERD-like symptoms with <SPAN class='\"\\"GRnoSuggestion\"' grcontextid='\"\\"dabigatran:3\\"\"' grmarkguid='\"\\"bac460cf-4bed-47d4-a7ab-7a92149aeb09\\"\"' gruiphraseguid='\"\\"bacc8c94-6284-412c-bcc8-92a662ef2f1b\\"\"' grcorrect\\\?='\"\"'>dabigatran (not shown)</SPAN>.<SPAN 1.4;\\\?='\"\"' line-height:='\"\"' 12pt;='\"\"' font-size:='\"\"' sans-serif;='\"\"' arial,='\"\"'></SPAN><span class='ref_num'>[96]</span></P><SPAN mso-bidi-font-weight:bold\\\?='\"\"' mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa;='\"\"' roman&quot;;='\"\"' roman&quot;;mso-bidi-font-family:&quot;times='\"\"' new='\"\"' mso-fareast-font-family:&quot;times='\"\"'></SPAN>&nbsp;<B><SPAN class='\"\\"GRnoSuggestion\"' grcontextid='\"\\"Reiffel:0\\"\"' grmarkguid='\"\\"842ef261-5837-4b00-a55e-58095df7bfbc\\"\"' gruiphraseguid='\"\\"4080c6a1-e738-4925-9f93-300edf9878fa\\"\"' grcorrect\\\?='\"\"'>Reiffel</SPAN> JA. <I>Am J <SPAN class='\"\\"GRcorrect\\"\"' grcontextid='\"\\"Med:0\\"\"' grmarkguid='\"\\"2609f69c-9464-4161-9821-b3f28782144d\\"\"' gruiphraseguid='\"\\"05b6dce9-f5b1-4d5c-bdf2-0e5ffe85246a\\"\"'>Med</SPAN></I> 2013; 126: 00-00.&nbsp;</B>   </div>


  <div class='figure_references' speaker='reiffelB' figure='25'>
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  <a href="complete_references.php" class="noprint right resource_link buttonify" target_orig="_blank">Complete references for all slides</a>
  <h2>References</h2>
    <p>
    <span class="ref_num">[96]</span> Connolly SJ, Ezekowitz MD, Yusuf S, et al; RE-LY Steering Committee and Investigators. Dabigatran versus warfarin in patients with atrial fibrillation. <i>N Engl J Med.</i> 2009;361:1139-1151.  </p>
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