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<h3 class='figure_identifier'>Steven A. Rothman, MD - AFib Treatment: General Population - Figure 24</h3>
<h2>Therapeutic Range for Warfarin</h2>


<div class='figure_text' speaker='rothman' figure='24'>
      
      <p><span class='\"GingerNoCheckStart\"'></span>This <b>Figure</b> depicts the odds ratios for risk of thromboembolic events and risks of intracranial hemorrhage <span class='\"\\"GRcorrect\\"\"' grcontextid='\"\\"vs:0\\"\"' grmarkguid='\"\\"139c932a-011a-4fd4-a6ea-7256bb8e08ab\\"\"' gruiphraseguid='\"\\"6f6c710d-9156-4ace-93b9-75faffb07dc9\\"\"'>vs</span> serum INR levels.<span roman&quot;;mso-bidi-font-family:&quot;times='\"\"' mso-fareast-font-family:&quot;times='\"\"' new='\"\"' roman&quot;;='\"\"' mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa;='\"\"' mso-bidi-font-weight:bold\\\?='\"\"'><span class="ref_num">[74]</span> </span>The clinical target for anticoagulation therapy is an INR target between 2 and 3, the point where physicians want to keep most of their patients with AFib. The risk of stroke increases below an INR of 1.8, and the risk of intracranial hemorrhage starts to increase at an INR above the 3.1 to 3.5 range. Thus, as evident in the Figure, the range of maximum benefit and minimum risk is a <span class='\"\\"GRnoSuggestion\"' grcontextid='\"\\"warfarin:0\\"\"' grmarkguid='\"\\"762b32d9-3d45-4c9b-9444-cc7df1856062\\"\"' gruiphraseguid='\"\\"6f56c8b6-b07d-4893-9fb4-effdbc2825a8\\"\"' grcorrect\\\?='\"\"'>warfarin</span> INR level between 1.8-1.9 and 3.1-3.5; this means maintaining an INR between 2 and 3 will be safe and effective, but that is a very narrow therapeutic window. </p>
<p><b>Rothman SA. <i>Am J <span class='\"\\"GRcorrect\\"\"' grcontextid='\"\\"Med:0\\"\"' grmarkguid='\"\\"6360cb6f-426a-486d-b66f-a26bc6ec4efa\\"\"' gruiphraseguid='\"\\"0aa30355-30f2-46ab-aa91-55979bb1af82\\"\"'>Med</span></i> 2013; 126: 00-00.&nbsp;</b><br class='\"\\"aloha-end-br\\"\"'></p><span class='\"GingerNoCheckEnd\"'></span>    </div>


  <div class='figure_references' speaker='rothman' figure='24'>
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  <a href="complete_references.php" class="noprint right resource_link buttonify" target_orig="_blank">Complete references for all slides</a>
  <h2>References</h2>
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    <span class="ref_num">[74]</span> Singer DE, Chang Y, Fang MC, et al. Should patient characteristics influence target anticoagulation intensity for stroke prevention in nonvalvular atrial fibrillation?: the ATRIA study. <i>Circ Cardiovasc Qual Outcomes.</i> 2009;2:297-304.  </p>
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