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<h3 class='figure_identifier'>James A. Reiffel, MD - Novel Oral Anticoagulants - Figure 22</h3>
<h2>Significant risk reduction</h2>


<div class='figure_text' speaker='reiffelB' figure='22'>
      <P>The <B>Figure</B> shows the risk reduction with <SPAN class='\"GRnoSuggestion' gruiphraseguid='\"1d359e8e-314a-45fb-bf3c-79fe42407333\"' grmarkguid='\"9980d709-cf4b-480f-848e-86634591eddc\"' grcontextid='\"dabigatran:0\"' GRcorrect\?>dabigatran</SPAN> 150 mg <SPAN class='\"GRnoSuggestion' gruiphraseguid='\"1d359e8e-314a-45fb-bf3c-79fe42407333\"' grmarkguid='\"91887a27-2642-4dc5-ba29-d278925c6c01\"' grcontextid='\"vs:1\"' GRcorrect\?>vs</SPAN> <SPAN class='\"GRcorrect\"' gruiphraseguid='\"1d359e8e-314a-45fb-bf3c-79fe42407333\"' grmarkguid='\"58888b33-9f5f-4473-94c9-21640b33ee8f\"' grcontextid='\"warfarin:2\"'>warfarin</SPAN> for all of the components of the primary endpoint.<SPAN style="FONT-FAMILY: 'Arial', 'sans-serif'" mso-bidi-font-weight:bold\? mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA; Roman&quot;; New Roman&quot;;mso-bidi-font-family:&quot;Times mso-fareast-font-family:&quot;Times 12.0pt? font-size:><SUP></SUP><span class='ref_num'>[104]</span><BR></SPAN>The reduction was statistically significant for all of the components (all strokes, ischemic strokes, hemorrhagic strokes) except systemic embolism (HR 0.61, NS). &nbsp;All endpoints were reduced with <SPAN class='\"GRnoSuggestion' gruiphraseguid='\"6ca089c0-4802-4902-83e2-a0fd4cfef570\"' grmarkguid='\"656a9e3f-4cd9-476d-a57a-040fb183397d\"' grcontextid='\"dabigatran:0\"' GRcorrect\?>dabigatran</SPAN> versus <SPAN class='\"GRnoSuggestion' gruiphraseguid='\"6ca089c0-4802-4902-83e2-a0fd4cfef570\"' grmarkguid='\"9253bf3b-7c9d-4a5c-a308-badd32831be4\"' grcontextid='\"warfarin:1\"' GRcorrect\?>warfarin</SPAN>, and they were done so similarly in all prespecified subgroups.</P>
<P>&nbsp;<B><SPAN class='\"GRnoSuggestion' gruiphraseguid='\"1bd9656b-ebdf-4967-ae8c-a5bdcfb0ae66\"' grmarkguid='\"adb7c88c-97ff-4f7d-88f8-94441116dcaa\"' grcontextid='\"Reiffel:0\"' GRcorrect\?>Reiffel</SPAN> JA. <I>Am J <SPAN class='\"GRcorrect\"' gruiphraseguid='\"4e96f3c1-3ae7-4c20-a5ae-adce8e4e15a1\"' grmarkguid='\"d0e74e71-5278-47a0-a665-377733515f1a\"' grcontextid='\"Med:0\"'>Med</SPAN></I> 2013; 126: 00-00.</B><BR class='\"aloha-end-br\"'></P>  </div>


  <div class='figure_references' speaker='reiffelB' figure='22'>
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  <a href="complete_references.php" class="noprint right resource_link buttonify" target_orig="_blank">Complete references for all slides</a>
  <h2>References</h2>
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    <span class="ref_num">[104]</span> Pradaxa&reg; (dabigatran etexilate mesylate) capsules [prescribing information]. Ridgefield, CT: <i>Boehringer Ingelheim Pharmaceuticals, Inc.</i>; 2010. Revised: December 2012.  </p>
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