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The Figure shows the intracranial and non-intracranial bleeding rates in a large cohort of about 13,000 patients with AFib.[68] Although it is clear that both kinds of bleeding risk increase with age, intracranial hemorrhage really increases only in the patients aged >80 years. Non-intracranial bleeding increases in patients >80 years of age only when not on warfarin. Intracranial bleeding risk increases in patients >80 years of age independent of warfarin use, and therefore the risk/benefit ratio again remains in favor of anticoagulation in this elderly population.
Rothman SA. Am J Med 2013; 126: 00-00.
[68] Fang MC, Go AS, Hylek EM, et al. Age and the risk of warfarin-associated hemorrhage: The Anticoagulation and Risk Factors In Atrial Fibrillation Study. J Am Geriatr Soc. 2006;54:1231-1236.