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<h3 class='figure_identifier'>James A. Reiffel, MD - Novel Oral Anticoagulants - Figure 13</h3>
<h2>Dabigatran Etexilate</h2>


<div class='figure_text' speaker='reiffelB' figure='13'>
      <P></P>
<P><SPAN class='\"GingerNoCheckStart\"'></SPAN>The <B>Figure</B> illustrates the close association between dose and the serum concentration – the relationship between the administered dose of <SPAN class='\"\\"GRnoSuggestion\"' gruiphraseguid='\"\\"df9bd110-7578-4361-8309-d11f17572f99\\"\"' grmarkguid='\"\\"4b764ae0-842a-48fc-880e-1a79d5a48b90\\"\"' grcontextid='\"\\"dabigatran:0\\"\"' grcorrect\\\?='\"\"'>dabigatran</SPAN> and the resulting plasma levels is virtually linear<SPAN mso-bidi-font-weight:bold\\\?='\"\"' mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa;='\"\"' roman&quot;;='\"\"' roman&quot;;mso-bidi-font-family:&quot;times='\"\"' new='\"\"' mso-fareast-font-family:&quot;times='\"\"'>.<span class='ref_num'>[105]</span><BR></SPAN>&nbsp;In addition, the association of serum concentration to anticoagulant effect is also very close, and it is these close associations that explain why no anticoagulant monitoring test is needed during therapy.&nbsp;</P>
<DIV>&nbsp;<B><SPAN class='\"\\"GRnoSuggestion\"' gruiphraseguid='\"\\"b4ab3cc3-5c7d-4b12-a2a4-ddb7bb1bfdd1\\"\"' grmarkguid='\"\\"c0321140-9787-4fa8-8266-be4ea7cd8553\\"\"' grcontextid='\"\\"Reiffel:0\\"\"' grcorrect\\\?='\"\"'>Reiffel</SPAN> JA. <I>Am J <SPAN class='\"\\"GRcorrect\\"\"' gruiphraseguid='\"\\"f2163ecc-4390-4898-bdb3-a2e2e8557b1b\\"\"' grmarkguid='\"\\"207e2b22-0764-4d63-96b6-e11e985ad171\\"\"' grcontextid='\"\\"Med:0\\"\"'>Med</SPAN></I> 2013; 126: 00-00.</B><BR></DIV>
<P></P><SPAN class='\"GingerNoCheckEnd\"'></SPAN>  </div>


  <div class='figure_references' speaker='reiffelB' figure='13'>
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  <h2>References</h2>
    <p>
    <span class="ref_num">[105]</span> Stangier J. Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate. <i>Clin Pharmacokinet.</i> 2008;47:285-295.  </p>
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