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<h3 class='figure_identifier'>William French, MD - Anticoagulation: Special Populations - Figure 13</h3>
<h2>Female Trial Enrollments</h2>


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      <p>A second aspect of the positive data for women seen in the previous Figure is the representation of females in the pivotal clinical trials of the NOACs: as shown in the <b>Figure</b> this&nbsp;has been high by historical standards, in the 35-40% range.<span class="ref_num">[121]</span> <span class="ref_num">[125]</span> <span class="ref_num">[129]</span> This ensures that, going forward, it will be possible to optimize the understanding of the NOACs in females, which is important because it reflects the higher risk of disease events, and the greater benefit of therapy, in women (and the elderly) in clinical practice.</p>
<p><b>French WJ. <i>Am J <span class='\"GRcorrect\"' grcontextid='\"Med:0\"' grmarkguid='\"7bdbd4f0-d26e-4a29-ba81-e52520996b50\"' gruiphraseguid='\"c7e6ef1d-d667-4f5b-8cdc-d301036a8516\"'>Med</span></i> 2013; 126: 00-00.</b><br class='\"aloha-end-br\"'></p>    </div>


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  <h2>References</h2>
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    <span class="ref_num">[121]</span> Patel MR, Mahaffey KW, Garg J, et al; the ROCKET AF Steering Committee, for the ROCKET AF Investigators. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. <i>N Engl J Med</i>. 2011;365:883-891.  </p>
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    <span class="ref_num">[125]</span> Granger CB, Alexander JH, McMurray JV, et al; the ARISTOTLE Committees and Investigators. Apixaban versus warfarin in patients with atrial fibrillation. <i>N Engl J Med.</i> 2011;365:981-992.  </p>
    <p>
    <span class="ref_num">[129]</span> Connolly SJ, Ezekowitz MD, Yusuf S, et al; RE-LY Steering Committee and Investigators. Dabigatran versus warfarin in patients with atrial fibrillation. <i>N Engl J Med.</i> 2009;361:1139-1151.  </p>
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