Unable to display view head.php file not found.
 
 

Reiffel - Atrial Fibrillation and Stroke: Epidemiology - Figure 11

Factors contributing to increased stroke risk


There are 3 principal factors that contribute to the increased risk for stroke in patients with nonvalvular AFib: 

  • Abnormal changes in the atrial wall
  • Abnormal blood stasis
  • Abnormal changes in the blood constituents

What is it about each of these factors that contributes to increased risk for stroke and non-valvular AFib, and what is it about AFib that adds to this risk?  
In AFib, particularly in the setting of structural disorders, there are abnormal changes in the atrial wall – atrial tissue changes, endothelial damage, and endothelial dysfunction, (which we will come back in a moment).[20] This is an important and often overlooked component of this problem.  
Also in AFib, when the atrial wall fibrillates it leads to abnormal stasis in the blood flow, and this hemodynamic change may add to the risk imposed by the disorders that affect the atrial wall and endothelium.  
Finally, there may be abnormal changes in the blood constituents – the activation and coagulation cascade components – in the fibrillating atrium, and these will be discussed as well.

Reiffel JA. Am J Med 2013; 126: 00-00.

Complete references for all slides

References

[20] Watson T, Shantsila E, Lip GY. Mechanisms of thrombogenesis in atrial fibrillation: Virchow's triad revisited. Lancet. 2009;373:155-166.

Unable to display view foot.php file not found.