Fig. 01 -

Title Slide

Fig. 02 -

Disclosures

Fig. 03 -

Outline

Fig. 04 -

Prevalence and Incidence

Fig. 05 -

HypnoLaus study

Fig. 06 -

Untreated OSA

Fig. 07 -

Pathogenesis

Fig. 08 -

Mechanisms and Consequences

Fig. 09 -

Co-Morbidities

Fig. 10 -

Type II Diabetes

Fig. 11 -

Cardiovascular Disease

Fig. 12 -

Breathing and Mortality

Fig. 13 -

Office Evaluation

Fig. 14 -

The Problem

Fig. 15 -

The essentials

Fig. 16 -

Clinical Prediction Formulas

Fig. 17 -

Conclusion

Fig. 18 -

Classic Physical Findings

Fig. 19 -

Sleep Test

Fig. 20 -

Polysomnography

Fig. 21 -

30 sec epoch

Fig. 22 -

Arousal & Apnea

Fig. 23 -

Portable Monitor

Fig. 24 -

Detailed Signal View

Fig. 25 -

Best Practice Approach

Fig. 26 -

Complete Treatment

Fig. 27 -

Effective AHI

Fig. 28 -

Inadequate

Fig. 29 -

3-4 Hours of CPAP

Fig. 30 -

Wisconsin Sleep Cohort

Fig. 31 -

Longitudinal Analysis

Fig. 32 -

Differential Effects

Fig. 33 -

Consult

Fig. 34 -

Cardiovascular Outcomes

Fig. 35 -

Not Optimal

Fig. 36 -

BP Effects

Fig. 37 -

OSA RCTs

Fig. 38 -

SAVE Trial

Fig. 39 -

Positive Pressure

Fig. 40 -

Therapy and Adherence

Fig. 41 -

Conclusion

Fig. 42 -

Cardiovascular Risk

Fig. 43 -

Oral Appliances

Fig. 44 -

Appliance Effects

Fig. 45 -

OAT

Fig. 46 -

Pathways

Fig. 47 -

Upper-Airway Stimulation

Fig. 48 -

ADHERE Registry

Fig. 49 -

Update

Fig. 50 -

Icelandic Sleep Cohort

Fig. 51 -

Heat Map

Fig. 52 -

Effect of CPAP

Fig. 53 -

HIPARCO

Fig. 54 -

Predicting BP Response

Fig. 55 -

Conclusions

Fig. 56 -

Dx and Rx

Fig. 57 -

Thank You