Murphy - Figure 5

NIV in acute hypercapnic respiratory failure is best practice

FIG. 5: Treatment with NIV is accepted as the gold standard care for patients with decompensated hypercapnic exacerbations of COPD. The evidence base has accumulated from a number of high-quality studies, with evidence suggesting reduced mortality, reduced intubation rates, as well as reduced lengths of stay.[4-9] These data have come from a range of hospital-based critical care and ward-based studies, but all have consistently shown that very low numbers of patients need to be treated to gain an advantage in this area.

Murphy P. Chest 2017:00.

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Martin TJ, Hovis JD, Costantino JP, et al. A randomized, prospective evaluation of noninvasive ventilation for acute respiratory failure. Am J Respir Crit Care Med. 2000;161(3 Pt 1):807−13. doi: 10.1164/ajrccm.161.3.9808143.

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Plant PK, Owen JL, Elliott MW. Early use of non-invasive ventilation for acute exacerbations of chronic obstructive pulmonary disease on general respiratory wards: a multicentre randomised controlled trial. Lancet. 2000;355:1931−5.

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Lightowler JV, Wedzicha JA, Elliott MW, Ram FS. Non-invasive positive pressure ventilation to treat respiratory failure resulting from exacerbations of chronic obstructive pulmonary disease: Cochrane systematic review and meta-analysis. BMJ. 2003;326:185.