Fig. 01 -

Title Slide

Fig. 02 -

Disclosures

Fig. 03 -

Exacerbations

Fig. 04 -

NIV

Fig. 05 -

Best Practice

Fig. 06 -

Outcomes

Fig. 07 -

Should We Start?

Fig. 08 -

Rescue Study

Fig. 09 -

Baseline Data

Fig. 10 -

Baseline Characteristics

Fig. 11 -

No Difference

Fig. 12 -

Patient Phenotyping

Fig. 13 -

Chronic Respiratory

Fig. 14 -

Hypothesis

Fig. 15 -

Trial Design

Fig. 16 -

Randomised Clinical Trial

Fig. 17 -

Inclusion Criteria

Fig. 18 -

In Patient Admission

Fig. 19 -

Pack Year History

Fig. 20 -

Following Resolution

Fig. 21 -

Exclusion Criteria

Fig. 22 -

Wean off NIV

Fig. 23 -

Primary Diagnosis

Fig. 24 -

Assessment

Fig. 25 -

Post Extubation

Fig. 26 -

Unable to Tolerate

Fig. 27 -

Inability to Consent

Fig. 28 -

Target Population

Fig. 29 -

Follow Up

Fig. 30 -

Exacerbation Definitions

Fig. 31 -

Criteria

Fig. 32 -

Titration

Fig. 33 -

Ventilation Strategy

Fig. 34 -

Recruitment

Fig. 35 -

Total Excluded

Fig. 36 -

Declined, Died & Inability

Fig. 37 -

BMI, Decompensated & OSA

Fig. 38 -

Arterial Blood Gases

Fig. 39 -

Suitable for Assessment

Fig. 40 -

Drop out Rate

Fig. 41 -

No Patients Lost

Fig. 42 -

Baseline Age

Fig. 43 -

Neck Circumference

Fig. 44 -

Median BMI

Fig. 45 -

Sleep Disordered Breathing

Fig. 46 -

No Significant OSA

Fig. 47 -

Intervention

Fig. 48 -

Primary Outcome

Fig. 49 -

Median Admission Free

Fig. 50 -

Control

Fig. 51 -

Mean & Max TcCO2

Fig. 52 -

Diagnostic and Treatment

Fig. 53 -

Daytime Hypercapnia

Fig. 54 -

Baseline to 3 Months

Fig. 55 -

Effect on Health

Fig. 56 -

28 Day Readmission

Fig. 57 -

Mortality

Fig. 58 -

Exacerbations

Fig. 59 -

Significant

Fig. 60 -

Conclusion