Schaefer - Figure 19 - CETP – HDL complexes Text
This Figure shows how a group in the United Kingdom thinks that CETP inhibitors work.[32],[33] They have proposed that CETP is like a shuttle that goes back and forth between VLDL and HDL, and when it sits on VLDL, it picks up triglyceride, then shunts back over to HDL and delivers the triglyceride and picks up cholesterol, and goes back and forth. The difficulty is that it did not always work perfectly, but now, it seems to be working much better.
J Clin Lipidol. 2011; 5(6).References
[32]Qiu X, Mistry A, Mark J Ammirati MJ, et al. Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules. Nat Struct Mol Biol. 2007;14:106-113.
[33]Clark RW, Ruggeri RB, Cunningham D, Bamberger MJ. Description of the torcetrapib series of cholesteryl ester transfer protein inhibitors, including mechanism of action. J Lipid Res 2006;47:537-552.