Schaefer - Figure 14 - Effects of simvastatin/niacin Text
This Figure shows a comparison similar to the previous Figure, only this time using the same gel electrophoresis technique to separate out HDL particle sizes to assess the effects of simvastatin plus niacin on the HDL particle size spectrum. These data are from the HATS trial by Dr. Greg Brown,[29] which demonstrated a significant regression of CHD with this drug combination, and the gel electrophoresis data[30] clearly showed that this was associated with a transition of the HDL particle spectrum from the small particles (which decreased 39%) to the large particles (which increased 115%).
J Clin Lipidol. 2011; 5(6).References
[29]HATS: Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001; 345:1583-92.
[30]Particle size analysis: Asztalos BF, Batista M, Horvath KV, Cox CE, Dallal GE, Morse JS, Brown GB, Schaefer EJ. Change in alpha 1 HDL concentration predicts progression in coronary artery stenosis. Arterioscler Thromb Vasc Biol 2003;23:847-852.