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<h2>Barter - Figure 22 - Future of CETP inhibition</h2>

  <p>
With all of this evidence:
<ul>
  <li>the evidence in rabbits that inhibiting CETP protects;</li>
  <li>the explanation for the failure of torcetrapib in the ILLUMINATE trial may

be the result of off-target pharmacologic effects, unrelated to CETP inhibition

(stressing that this may be the case, because this is not proof).</li>
</ul>

What is the future of CETP inhibition as an anti-atherogenic strategy? As listed in

the <b>Figure</b>, there appears to be a compelling case for further testing the hypothesis that

inhibiting CETP will be anti-atherogenic in humans, so long as the hypothesis is tested

with inhibitors that do not share the off-target pharmacology of torcetrapib. To prove

this, it will be necessary to investigate this hypothesis in clinical outcome trials.
</p>
<span class='figuretext_source_identifier'>
  <span class="author">Barter P.</span>
  <span class="publication">J Clin Lipidol.</span>
  <span class="identifier">2011; 5(6).</span>
</span>
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