Toth - Figure 4 - Genetics -1 - Familial Hypercholesterolemia: Prevalence, Genetics, Diagnosis, and Screening - Diagnosis and Management of Familial Hypercholesterolemia in Children and Adults

Toth - Figure 4 - Genetics -1 Text

FH is defined as an autosomal dominant trait with complete penetrance causing congenitally elevated levels of LDL cholesterol. There is a gene/dosage effect, with homozygotes having significantly greater elevations of LDL cholesterol and earlier cardiovascular disease (CVD) onset than heterozygotes.

Toth PP. J Clin Lipidol. 2011; 5(6).