Cascade screening involves testing lipid levels in all first-degree relatives of diagnosed FH patients. As cascade screening proceeds, the occurrence of newly identified FH cases will provide additional relatives who should be considered for screening. Cascade screening has been shown to be the most cost effective means of finding previously undiagnosed FH patients and is also cost effective in terms of cost per year of life saved.
J Clin Lipidol. 2011; 5(6).