Rader - Figure 7 - Does efflux capacity correlate with CVD?
The next question was whether this measure of HDL “efflux capacity” was a biomarker
that correlates with atherosclerotic CVD burden. To assess this we carried out 2 studies:
- one study was performed in a group of basically healthy individuals who had
their carotid intimal medial thickness (cIMT) measured; this is a measure of
atherosclerotic disease that has been widely used in research.
- the second group consisted of individuals who had undergone coronary
angiography and consequently were found either to have coronary angiographic
disease (CAD) or to be, in effect, controls – ie, have “clean” coronary arteries.
The question in both studies was, Is “cholesterol efflux capacity” associated with severity
of disease, as assessed by either cIMT or coronary angiography?
Rader D.
J Clin Lipidol.
2011; 5(6).
