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McGowan - Figure 4 - FH: Pattern of Autosomal Recessive Inheritance

This Figure is a cartoon illustrating the dominant pattern of inheritance in two heterozygote parents.  Simple Mendelian inheritance predicts that the chance of one of their children inheriting heterozygous FH will be 2 in 4, or 50%.  The chance of having a child with homozygous FH, which confers an LDL-C level 3–6-fold higher than in the general population, would be 1 in 4, or 25%. 

McGowan J Clin Lipidol. 2012;
Complete references for all slides

References

[10] Soutar AK, et al. Arterioscler Thromb Vasc Biol. 2003;23(11):1963-1970.

[11] Pisciotta L, et al. Atherosclerosis. 2006;188(2):398-405.

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