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<h2>Rader - Figure 20 - Current therapies for lowering LDL converge on upregulation of the hepatic LDL receptor</h2>


<div class='figure_text' speaker='rader' figure='20'>
      
      Therapy for patients with heterozygous FH in general is simply the standard lipid-lowering therapy currently available, meaning high-dose <span class="GRspelling">statins,</span> and then, if needed, cholesterol absorption inhibitors and bile acid <span class="GRspelling">sequestrants,</span> all of which target the normal LDL receptor allele, resulting in up-regulation of the LDL receptor and lowering of circulating LDL-C.&nbsp; This is how lipid-lowering therapy should work, and of course many heterozygous FH patients are reasonably responsive to standard LDL-lowering therapy, based on up-regulation of the LDL receptor.<br style="\&quot;\&quot;">    </div>
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  <span class="author">Rader</span>
  <span class="publication">J Clin Lipidol.</span>
  <span class="identifier">2012;</span>
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