CHEST® Resource Center

Dreher - Figure 34

NIV after acute hypercapnic COPD The HOT HMV trial (multicenter trial)

Fig. 34: The suggestion that future studies should enroll patients with persistent hypercapnia several weeks after the acute exacerbation episode was addressed in the HOT HMV (Home Oxygen Therapy versus Home Mechanical Ventilation for Chronic Obstructive Pulmonary Disease) multicenter trial in the UK.[16] Patients with prolonged hypercapnia (PaCO2 >7 kPa) were randomized to either home oxygen therapy (HOT) or home mechanical ventilation (HMV) at 14 to 48 days after resolution of the acute respiratory failure event. Based on an assumption that only patients with acute-on-chronic hypercapnic respiratory failure will be included, the results of this study are awaited with interest.[17].

Dreher M. Chest 2016;00.

References

[16]

Home mechanical ventilation vs home oxygen therapy in COPD. ClinicalTrials.gov Identifier: NCT00990132. https://clinicaltrials.gov/ct2/show/NCT00990132

[17]

Murphy P, Arbane G, Bourke S, et al. Improving admission free survival with home mechanical ventilation (HMV) and home oxygen therapy (HOT) following life threatening COPD exacerbations: HoT-HMV UK Trial NCT00990132 Presented at the European Respiratory Society (ERS) International Congress 2016, September 3–7, 2015, London, UK.