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            <i>American Journal of Medicine</i>          </div>
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<h2>Efficacy and Safety of NOACs vs. Warfarin: Systematic reviews and meta-analyses</h2>
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<div class='figure_text' speaker='camm' figure='13'>
      
      
      
      <p>There have been several meta-analyses of the value of the NOACs versus <span class="GINGER_SOFATWARE_noSuggestion GINGER_SOFATWARE_correct" grcontextid="warfarin:0" ginger_sofatware_markguid="b1c3f087-d3f5-4532-908d-3ff3963939f0" ginger_sofatware_uiphraseguid="b726b8da-e0ac-4b3f-8bc1-c3b16fd2f89a">warfarin</span>. &nbsp;<b>Figure 13</b> (right) illustrates an analysis published by Dentali.<span class='ref_num'>[20]</span><sup></sup>&nbsp; Looking at the NOACs together, we can see that there is a significant reduction in all-cause mortality and cardiovascular mortality, both about 11%; a significant reduction in stroke or systemic embolism, about 23%; and a significant reduction in intracranial hemorrhage, approximately 54%. &nbsp;There are also trends towards a reduction of ischemic stroke and major bleeding. &nbsp;<b>Camm J. <i>Am J <span class="GINGER_SOFATWARE_correct" grcontextid="Med:0" ginger_sofatware_markguid="45e22f3d-7bc1-4495-a2e6-26304d7f7f60" ginger_sofatware_uiphraseguid="88481cc1-c0a0-40a7-b525-fb621bfbb2dc">Med</span> </i>2013</b>; published on-line at http://education.amjmed.com/00000.<br class="aloha-end-br"></p>
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  <h2>References</h2>
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    <span class="ref_num">[19]</span> Lip GY, Edwards SJ. Stroke prevention with aspirin, warfarin and ximelagatran in patients with non-valvular atrial fibrillation: a systematic review and meta-analysis. <i>Thromb Res</i>. 2006;118:321-333.  </p>
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    <span class="ref_num">[20]</span> Dentali F, Riva N, Crowther M, et al. Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: a systematic review and meta-analysis of the literature. <i>Circulation</i>. 2012;126:2381-2391.  </p>
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