Unable to display view head.php file not found.<div id='slide_area'>
  <div class='slide'>
          <center>
    <table class='layout' width_old='700'>
      <tr>
        <td width='135'>
          <div class="slide_nav_container">
          <center>
                    <a href="figure.php?speaker=eikelboom&figure=7" class='slide_link buttonify center nextprev_button'>&laquo;&nbsp;Prev</a>
                    </center>
          </div>
        </td>
        <td width='420'>
          <div class='slide_image'>
                                                <a href="figure_images/eikelboom/figure8_large.png" class="overlay" title="Targets of New Interventions">
                                        <img src="figure_images/eikelboom/figure8_w420.png" border='0'>
                                      </a>
                      </div>
        </td>
        <td width='135'>
          <div class="slide_nav_container">
          <center>
                    <a href="figure.php?speaker=eikelboom&figure=9" class='slide_link buttonify center nextprev_button'>Next&nbsp;&raquo;</a>
                    <br>
          <a href="figure_images/eikelboom/figure8_large.png" class="overlay_alternate slide_link buttonify">Click Figure to Enlarge</a>
          </center>
          </div>
        </td>
      </tr>
      <tr>
        <td>&nbsp;</td>
        <td>
                    <div class='slide_layout_control'>
                      <div id="jquery_jplayer_1" class="jp-jplayer"></div>
  <div id="jp_container_1" class="jp-audio">
    <div class="jp-type-single">
      <div class="jp-gui jp-interface">
          <div style="display: none;">
            <!-- jPlayer 2.1.0 breaks in IE if the video stuff isn't found (css selectors warning), so uh, put them in, but hide them -->
            <a href="javascript:;" class="jp-video-play" tabindex="1">play</a>
            <a href="javascript:;" class="jp-full-screen" tabindex="1">full</a>
            <a href="javascript:;" class="jp-restore-screen" tabindex="1">restore</a>
          </div>
        <ul class="jp-controls">
          
          <li><a href="javascript:;" class="jp-play" tabindex="1">play</a></li>
          <li><a href="javascript:;" class="jp-pause" tabindex="1">pause</a></li>
          <li><a href="javascript:;" class="jp-stop" tabindex="1">stop</a></li>
          <li><a href="javascript:;" class="jp-mute" tabindex="1" title="mute">mute</a></li>
          <li><a href="javascript:;" class="jp-unmute" tabindex="1" title="unmute">unmute</a></li>
          <li><a href="javascript:;" class="jp-volume-max" tabindex="1" title="max volume">max volume</a></li>
        </ul>
        <div class="jp-progress">
          <div class="jp-seek-bar">
            <div class="jp-play-bar"></div>
          </div>
        </div>
        <div class="jp-volume-bar">
          <div class="jp-volume-bar-value"></div>
        </div>
        <div class="jp-time-holder">
          <div class="jp-current-time"></div>
          <div class="jp-duration"></div>
          <ul class="jp-toggles">
            <li><a href="javascript:;" class="jp-repeat" tabindex="1" title="repeat">repeat</a></li>
            <li><a href="javascript:;" class="jp-repeat-off" tabindex="1" title="repeat off">repeat off</a></li>
          </ul>
        </div>
      </div>
      <div class="jp-title"></div>
      <div class="jp-no-solution">
        <span>Update Required</span>
        To play the media you will need to either update your browser to a recent version or update your <a href="http://get.adobe.com/flashplayer/" target="_blank">Flash plugin</a>.
      </div>
    </div>
  </div>

  <script type="text/javascript">
    $(document).ready(function(){
      $("#jquery_jplayer_1").jPlayer({
        ready: function () {
        var jp_conf = {}; 
        jp_conf['oga'] = 'audio/eikelboom/figure8_audio.ogg';
        jp_conf['mp3'] = 'audio/eikelboom/figure8_audio.mp3';
          $(this).jPlayer("setMedia", jp_conf);
        },
        
        cssSelectorAncestor: '#jp_container_1',
        cssSelector: {
          videoPlay: '.jp-video-play',
          play: '.jp-play',
          pause: '.jp-pause',
          stop: '.jp-stop',
          seekBar: '.jp-seek-bar',
          playBar: '.jp-play-bar',
          mute: '.jp-mute',
          unmute: '.jp-unmute',
          volumeBar: '.jp-volume-bar',
          volumeBarValue: '.jp-volume-bar-value',
          volumeMax: '.jp-volume-max',
          currentTime: '.jp-current-time',
          duration: '.jp-duration',
          fullScreen: '.jp-full-screen',
          restoreScreen: '.jp-restore-screen',
          repeat: '.jp-repeat',
          repeatOff: '.jp-repeat-off',
          gui: '.jp-gui',
          noSolution: '.jp-no-solution'
        },

        
        swfPath: "//www.webedcafe.com/extern/program_media/lib/jQuery.jPlayer.2.1.0",
        solution: "html,flash",
        supplied: "oga, mp3"
        , errorAlerts: false //dies on videoPlay not being found otherwise, stupidly
        , warningAlerts: true
      });
    });
  </script>
                    </div>
                    <div id="transcript_branding_bar">
            <i>American Journal of Medicine</i>          </div>
                  </td>
        <td>&nbsp;</td>
      </tr>
    </table>
    </center>

  <script>
  /* a second call to colorbox for the "click to enlarge link" */
  $(document).ready(function() {
    var colorbox_conf = {};
    colorbox_conf.transition = "fade";
    
    colorbox_conf.maxWidth = "90%";
    colorbox_conf.maxHeight = "90%";
    colorbox_conf.top = "5%"; //it centers oddly on the whole document height, instead of the viewport, so force it to the top i guess
    $('.overlay_alternate').colorbox(colorbox_conf);
  });//end ready
  </script>

  </div>    
</div><!-- end slide area -->

<div class='with_figure_content'>
<div class='transcript'>
  <div class='right noprint'>
<a href="printable.php?speaker=eikelboom&figure=8" class="print_link buttonify" target_orig="_blank" style=''>Print This Page</a>
</div>


<!-- specific to glioblastoma video -->
<h2><span style="font-size:12px;">Eikelboom - Evidence from the Randomized Trials - Figure 8</span><br />Targets of New Interventions</h2>



<div class='figure_text' speaker='eikelboom' figure='8'>
      <P>What are the biologic targets for these new NOACs? &nbsp;<B>Figure 8 </B>shows the coagulation pathway where the trigger of coagulation is tissue injury and the exposure of tissue factor to the blood, as reviewed in the presentation by Dr. &nbsp;Weitz<SPAN class=ref_num>[5,</SPAN><SPAN class=ref_num>6]</SPAN>&nbsp; Unlike <SPAN class=GINGER_SOFATWARE_spelling ginger_sofatware_uiphraseguid="f709dab5-6e06-460c-b33b-3da5142e8dae">warfarin</SPAN> and heparin, which target multiple coagulation proteins, the NOACs <SPAN class=GINGER_SOFATWARE_spelling ginger_sofatware_uiphraseguid="f709dab5-6e06-460c-b33b-3da5142e8dae">rivaroxaban</SPAN> and <SPAN class=GINGER_SOFATWARE_spelling ginger_sofatware_uiphraseguid="f709dab5-6e06-460c-b33b-3da5142e8dae">apixaban</SPAN> selectively target factor Xa, and the other class of NOAC, represented by <SPAN class=GINGER_SOFATWARE_spelling ginger_sofatware_uiphraseguid="f709dab5-6e06-460c-b33b-3da5142e8dae">dabigatran,</SPAN> selectively targets <SPAN class=GINGER_SOFATWARE_spelling ginger_sofatware_uiphraseguid="f709dab5-6e06-460c-b33b-3da5142e8dae">thrombin.</SPAN>&nbsp; <FONT color=#000000 size=3 face="Times New Roman"><SPAN style="FONT-FAMILY: 'Helvetica', 'sans-serif'; COLOR: black; FONT-SIZE: 9pt; mso-fareast-font-family: Times; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA; mso-bidi-font-size: 10.0pt; mso-bidi-font-family: 'Times New Roman'"><B style="mso-bidi-font-weight: normal">Eikelboom J. <I style="mso-bidi-font-style: normal">Am J Med</I> 2013; </B>published on-line at </SPAN><SPAN style="FONT-FAMILY: 'Helvetica', 'sans-serif'; COLOR: rgb(0,0,102); FONT-SIZE: 9pt; mso-fareast-font-family: Times; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA; mso-bidi-font-size: 10.0pt; mso-bidi-font-family: AdvOT3c2d9f11">http://education.amjmed.com/00000.</SPAN><?XML:NAMESPACE PREFIX = U1 /><U1:P></U1:P></FONT>&nbsp;<BR class=aloha-end-br></P>  </div>




  <div class='figure_references' speaker='eikelboom' figure='8'>
  <div class="references">
  <!--
  <a href="complete_references.php" class="noprint right resource_link buttonify" target_orig="_blank">Complete references for all slides</a>
  -->
  <h2>References</h2>
    <p>
    <span class="ref_num">[5]</span> Weitz JI, Bates SM. New anticoagulants. <i>J Thromb Haemost</i>. 2005;3:1843-1853.  </p>
    <p>
    <span class="ref_num">[6]</span> Weitz JI, Hirsh J, Samama MM; American College of Chest Physicians. New antithrombotic drugs: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). <i>Chest</i>. 2008;133(6 Suppl):234S-256S.  </p>
  </div>
  </div>
  

  
  </div>
</div>
Unable to display view foot.php file not found.