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By “VTE” we mean deep vein thrombosis (DVT) and pulmonary embolism (PE) (Figure 2). VTE represents a very important healthcare problem that affects 1–2 persons per 1000 of the population each year, and it is an important cause of both morbidity and mortality. Eikelboom J. Am J Med 2013; published on-line at http://education.amjmed.com/00000.