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            <i>American Journal of Medicine</i>          </div>
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<h2><span style="font-size:12px;">Eikelboom - Evidence from the Randomized Trials - Figure 19</span><br />RE-SONATE: Any Bleeding</h2>



<div class='figure_text' speaker='eikelboom' figure='19'>
      <P>There was a substantial increase of about 40% to 50% in bleeding with <SPAN class=GINGER_SOFATWARE_spelling ginger_sofatware_uiphraseguid="d9879a7f-9848-47f0-9a0b-5b5d35de5809">dabigatran</SPAN> in RE-SONATE, which is what might be expected but is nonetheless an important finding as physicians weigh the balance between risk and benefits of extended treatment. <SPAN class=ref_num>[9]</SPAN> <SPAN class=ref_num><SPAN style="FONT-FAMILY: 'Helvetica', 'sans-serif'; COLOR: black; FONT-SIZE: 9pt; mso-fareast-font-family: Times; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA; mso-bidi-font-size: 10.0pt; mso-bidi-font-family: 'Times New Roman'"><B style="mso-bidi-font-weight: normal">Eikelboom J. <I style="mso-bidi-font-style: normal">Am J Med</I> 2013; </B>published on-line at </SPAN><SPAN style="FONT-FAMILY: 'Helvetica', 'sans-serif'; COLOR: rgb(0,0,102); FONT-SIZE: 9pt; mso-fareast-font-family: Times; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA; mso-bidi-font-size: 10.0pt; mso-bidi-font-family: AdvOT3c2d9f11">http://education.amjmed.com/00000.</SPAN><?XML:NAMESPACE PREFIX = U1 /><U1:P></U1:P><FONT color=#333333 size=2>&nbsp;</FONT></SPAN></P>  </div>




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  <h2>References</h2>
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    <span class="ref_num">[9]</span> Schulman S, Kearon C, Kakkar AK, et al; for the RE-MEDY and the RE-SONATE Trials Investigators. Extended use of dabigatran, warfarin, or placebo in venous thromboembolism. <i>N Engl J Med</i>. 2013;368:709-718.  </p>
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