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            <i>American Journal of Medicine</i>          </div>
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<h2><span style="font-size:12px;">Eikelboom - Evidence from the Randomized Trials - Figure 17</span><br />RE-SONATE Study Design</h2>



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The second long-term study with <span class="GINGER_SOFATWARE_noSuggestion GINGER_SOFATWARE_correct" ginger_sofatware_uiphraseguid="2844a286-d4de-46de-9d4b-86d7552862a6" ginger_sofatware_markguid="267dcec3-935f-4798-9679-8495143e8a38" grcontextid="dabigatran:0">dabigatran</span> is RE-SONATE. &nbsp;In this trial, patients who had completed 6 or 18 months of <span class="GINGER_SOFATWARE_correct" ginger_sofatware_uiphraseguid="9e7bf7f4-6482-40f4-8af7-c36ae531706b" ginger_sofatware_markguid="02214b42-517c-4ae5-9b5d-c928373cb90e" grcontextid="anticoagulants:0">anticoagulant</span> therapy were randomized to dabigatran etexilate at a dose of 150 mg twice daily or placebo. &nbsp;This means that RE-SONATE differed from the RE-MEDY trial because the comparator was <span class="GINGER_SOFATWARE_spelling" ginger_sofatware_uiphraseguid="9c8ad379-8b63-4bc1-bb4c-f7e02ee9c149">warfarin whereas</span> in RE-SONATE the comparator was placebo.<span class="ref_num">[9]&nbsp; </span><font color="#000000" face="Times New Roman" size="3"><span style='color: black; font-family: "Helvetica","sans-serif"; font-size: 9pt; mso-fareast-font-family: Times; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA; mso-bidi-font-size: 10.0pt; mso-bidi-font-family: "Times New Roman";'><b style="mso-bidi-font-weight: normal;">Eikelboom J. <i style="mso-bidi-font-style: normal;">Am J Med</i> 2013; </b>published on-line at </span><span style='color: rgb(0, 0, 102); font-family: "Helvetica","sans-serif"; font-size: 9pt; mso-fareast-font-family: Times; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA; mso-bidi-font-size: 10.0pt; mso-bidi-font-family: AdvOT3c2d9f11;'>http://education.amjmed.com/00000.</span><u1:p></u1:p></font>&nbsp;</p>
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  <h2>References</h2>
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    <span class="ref_num">[9]</span> Schulman S, Kearon C, Kakkar AK, et al; for the RE-MEDY and the RE-SONATE Trials Investigators. Extended use of dabigatran, warfarin, or placebo in venous thromboembolism. <i>N Engl J Med</i>. 2013;368:709-718.  </p>
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