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            <i>American Journal of Medicine</i>          </div>
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<h2><span style="font-size:12px;">Hylek - Prevention and Treatment of Venous Thromboembolism - Figure 13</span><br />EINSTEIN-DVT, EINSTEIN-PE, RE-COVER</h2>



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      <p><b>Figure 13</b> shows a pooled analysis of data from the EINSTEIN DVT, EINSTEIN PE, and RE-COVER trials.<span class='ref_num'>[7]</span> &nbsp;Dr. <span class="GINGER_SOFATWARE_noSuggestion GINGER_SOFATWARE_correct" grcontextid="Eikelboom:0" ginger_sofatware_markguid="ad8c97be-5463-4d35-ac0c-4014cb2122f7" ginger_sofatware_uiphraseguid="3e42ec0b-f9f1-4c2b-9b5b-7481e0fa08e7">Eikelboom</span> discusses these trials and their results in-depth in his presentation. &nbsp;The Forest plot in the right-hand side of this Figure shows that these agents are non-inferior to dose-adjusted warfarin, or are relatively the same; however the value for most of the risk ratios are close to the line of unity and all of the confidence-interval lines cross the line, which means that there is not really an overwhelmingly clear superiority for any of these agents <span class="GINGER_SOFATWARE_correct" grcontextid="over dose:0" ginger_sofatware_markguid="c44ed8a2-29de-47e3-911a-7b47a9a73160" ginger_sofatware_uiphraseguid="ab3e20e7-91e6-4213-8141-bae03e7c75d3">over dose</span>-adjusted warfarin.&nbsp; <font color="#000000" face="Times New Roman" size="3"><span style="color: rgb(51, 51, 51); font-family: &quot;Helvetica&quot;,&quot;sans-serif&quot;; font-size: 9pt; mso-fareast-font-family: Times; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;"><span style="mso-spacerun: yes;"></span></span><span style="color: black; font-family: &quot;Helvetica&quot;,&quot;sans-serif&quot;; font-size: 9pt; mso-fareast-font-family: Times; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA; mso-bidi-font-size: 10.0pt; mso-bidi-font-family: &quot;Times New Roman&quot;;"><span style="mso-spacerun: yes;"></span><b style="mso-bidi-font-weight: normal;"><span class="GINGER_SOFATWARE_noSuggestion GINGER_SOFATWARE_correct" grcontextid="Hylek:0" ginger_sofatware_markguid="a8ba4358-77cd-449f-bb05-9f3dcc210dfb" ginger_sofatware_uiphraseguid="c4fe3026-7c34-45b2-a734-bdea77862959">Hylek</span> E. <i style="mso-bidi-font-style: normal;">Am J <span class="GINGER_SOFATWARE_correct" grcontextid="Med:0" ginger_sofatware_markguid="aabcfd61-4673-41da-8f02-f059209941ab" ginger_sofatware_uiphraseguid="1a8f2c20-9f5a-4f3e-a53a-f1e49d84d7ee">Med</span></i> 2013; </b>published on-line at </span><span style="color: rgb(0, 0, 102); font-family: &quot;Helvetica&quot;,&quot;sans-serif&quot;; font-size: 9pt; mso-fareast-font-family: Times; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA; mso-bidi-font-size: 10.0pt; mso-bidi-font-family: AdvOT3c2d9f11;">http://education.amjmed.com/00000.</span><u1:p></u1:p></font>&nbsp;<br class="aloha-end-br"></p>
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  <h2>References</h2>
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    <span class="ref_num">[7]</span> Adam SS, McDuffie JR., Ortel TL, Williams Jr, JW. Comparative effectiveness of warfarin and new oral anticoagulants for the management of atrial fibrillation and venous thromboembolism: A systematic review. <i>Ann Intern Med</i>. 2012;157:796-807.  </p>
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