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            <i>American Journal of Medicine</i>          </div>
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<h2><span style="font-size:12px;">Eikelboom - Evidence from the Randomized Trials - Figure 13</span><br />RECOVER I: Bleeding</h2>



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      <p>What about bleeding? &nbsp;There was no significant difference in major bleeding between <span class="GINGER_SOFATWARE_spelling" ginger_sofatware_uiphraseguid="bc59510f-55c6-47bb-987a-381ba23bb082">warfarin</span> and <span class="GINGER_SOFATWARE_spelling" ginger_sofatware_uiphraseguid="bc59510f-55c6-47bb-987a-381ba23bb082">dabigatran</span> in RE-COVER I, but when we added all kinds of bleeds together, <span class="GINGER_SOFATWARE_spelling" ginger_sofatware_uiphraseguid="bc59510f-55c6-47bb-987a-381ba23bb082">dabigatran</span> substantially reduced the risk by about one-third (<b>Figure 13</b>).<span class="ref_num">[7]</span> &nbsp;So RE-COVER I showed us that in patients with VTE treated initially with standard parenteral treatment, <span class="GINGER_SOFATWARE_spelling" ginger_sofatware_uiphraseguid="bc59510f-55c6-47bb-987a-381ba23bb082">dabigatran</span> was as effective and somewhat safer than <span class="GINGER_SOFATWARE_spelling" ginger_sofatware_uiphraseguid="bc59510f-55c6-47bb-987a-381ba23bb082">warfarin</span> when continued out to 6 months.</p><p>

RE-COVER II has not yet been published, but this was a similarly designed trial included a somewhat broader spectrum of patients and produced similar results.&nbsp;&nbsp; <font color="#000000" face="Times New Roman" size="3"><span style='color: black; font-family: "Helvetica","sans-serif"; font-size: 9pt; mso-fareast-font-family: Times; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA; mso-bidi-font-size: 10.0pt; mso-bidi-font-family: "Times New Roman";'><b style="mso-bidi-font-weight: normal;">Eikelboom J. <i style="mso-bidi-font-style: normal;">Am J Med</i> 2013; </b>published on-line at </span><span style='color: rgb(0, 0, 102); font-family: "Helvetica","sans-serif"; font-size: 9pt; mso-fareast-font-family: Times; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA; mso-bidi-font-size: 10.0pt; mso-bidi-font-family: AdvOT3c2d9f11;'>http://education.amjmed.com/00000.</span><u1:p></u1:p></font>&nbsp;</p>
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    <span class="ref_num">[7]</span> Schulman S, Kearon C, Kakkar AK, et al; for the RE-COVER Study Group. Dabigatran versus warfarin in the treatment of acute venous thromboembolism. N Engl J Med. 2009;361:2342-2352. Eikelboom - figure 11, figure 12, figure 13
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