The Figure illustrates the important details of the pharmacologic characteristics of rivaroxaban.[97][113][114]For physicians and patients, an important feature of rivaroxaban is that it can be dosed once daily.  Rivaroxaban has predictable pharmacokinetics and pharmacodynamics,[97] but its absorption is dependent on taking it with food, particularly with the largest meals.[113] This is why the drug’s package insert says that it should be taken with the evening meal, once daily.  Rivaroxaban has a dual mode of clearance, via both renal and hepatic metabolism; the metabolites, however, are partially renally excreted, and so physicians should be aware that renal function is important in these patients.[97]

 Reiffel JA. Am J Med 2013; 126: 00-00.