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<h3 class='figure_identifier'>Steven A. Rothman, MD - AFib Treatment: General Population - Figure 23</h3>
<h2>Difficulties with Warfarin Use</h2>


<div class='figure_text' speaker='rothman' figure='23'>
      
      
      <p>

Finally Question #3 as to why oral anticoagulation therapy is underutilized concerns the difficulties with <span class='\"GRcorrect\"' gruiphraseguid='\"e1d3cc99-886d-4418-ab92-4f0e0e95ae40\"' grmarkguid='\"9c8b5a60-b35c-420f-8ac6-2c5d57a0ecce\"' grcontextid='\"use:0\"'>use</span> of <span class='\"GRnoSuggestion' gruiphraseguid='\"e1d3cc99-886d-4418-ab92-4f0e0e95ae40\"' grmarkguid='\"9fc3b099-b13b-44d2-a7b3-5a1f7ee60938\"' grcontextid='\"warfarin:1\"' GRcorrect\?="">warfarin</span>, the anticoagulant drug that has been in clinical use for the longest time. &nbsp;The well-known difficulties with <span class='\"GRnoSuggestion' gruiphraseguid='\"32c4cf78-8eb9-46b9-b98f-8475f9612cbf\"' grmarkguid='\"70ae548b-48e2-4cb0-8247-0f3cceacb4fc\"' grcontextid='\"warfarin:0\"' GRcorrect\?="">warfarin</span> are the very narrow therapeutic window, the multiple drug and food interactions, and finally there are genetic variations that make the use of <span class='\"GRcorrect\"' gruiphraseguid='\"32c4cf78-8eb9-46b9-b98f-8475f9612cbf\"' grmarkguid='\"bad60093-79b5-4987-9e78-f1ed617cdd50\"' grcontextid='\"warfarin:1\"'>warfarin</span> quite difficult.&nbsp;</p><p><b>Rothman SA. <i>Am J <span class='\"GRcorrect\"' gruiphraseguid='\"53b763d8-6a66-458c-ab24-b2075e84ca7d\"' grmarkguid='\"ab9e6992-23b1-4a50-b059-9cc265261132\"' grcontextid='\"Med:0\"'>Med</span></i> 2013; 126: 00-00.</b><br class='\"aloha-end-br\"'></p>
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