The conclusions from all these studies tell us that HPV testing combined with cytology (co-testing) increases
the CIN 2+ sensitivity for lesion detection, and that clinical sensitivity approaches 100%.
Even in women with a Pap normal result, about 9% have a positive High Risk HPV test result. HPV testing
has an excellent negative predictive value.
At the end of the day it saves lives.
[51] Ronco, G. et al. Human Papillomavirus testing and liquid-based cytology: results at recruitment from the new technologies for cervical cancer randomized controlled trial. J. Natl Cancer Inst 2006; 98(11):765-774
[50] Mayrand, M.H. et al. Human papillomavirus DNA versus Papanicolaou screening tests for cervical cancer. N. Engl J Med 2007; 357(16):1579-1588.
[62] CDC Study (Datta et al., Annals of Internal Medicine, 2008)
[63] Castle, PE, et al. Obstet Gynecol 2009;113:595–600
[64] European Cohort Study (Dillner, J. et al., BMJ, 2008)
[61] Sankaranarayanan, R. et al. HPV screening for cervical cancer in rural India. N Engl J Med 2009; 360(14):1385-1394.
